Prime Minister David Cameron is set to call for bars, supermarkets and the drinks industry in England to do more to help ensure responsible drinking.
On a visit to a hospital in north-east England, he will promise to tackle the "scandal" of drunkenness and alcohol abuse that costs the NHS £2.7bn a year.
He is set to suggest the use of US-inspired "drunk tanks", cells to house people overnight while they sober up.
The government will publish its alcohol strategy for England later this year.
A ban on the sale of alcohol below cost price - less than the tax paid on it - is set to be introduced in England and Wales from 6 April.
But ministers are expected to go further in the forthcoming strategy, recommending a higher minimum price for drink.
Scotland has already introduced an Alcohol Bill, which could become law before the summer, although ministers have yet to set a minimum price per unit.
But opponents of a minimum unit price say it is unfair because it penalises all drinkers, not just those who cause or have problems, and it is thought any move could be open to legal challenges relating to European competition law.
The British Beer and Pub Association has said it will make little or no difference to prices in supermarkets, where the majority of alcohol is bought, and would simply force more pubs out of business.
During his hospital visit, the prime minister is expected to criticise the "reckless" behaviour of an "irresponsible" minority and cite figures suggesting the alcohol-related costs to society as a whole may total between £17bn and £22bn a year.
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Meeting doctors, nurses, paramedics and police, Mr Cameron is set to say people in town centres, hospitals and police stations across the UK have to cope with the consequences of alcohol abuse every night and the problem is getting worse.
He will say that the last decade has seen a "frightening growth" in the number of people who think it is "acceptable for people to get drunk in public in ways that wreck lives, spread fear and increase crime", adding that many of those drinking to excess are under the legal drinking age.
Mr Cameron is expected to cite figures that suggest £1bn is spent on accident and emergency services alone dealing with issues related to alcohol abuse.
He is due to outline how the government will set attempt to help emergency services "rise to the challenge" when laying out its forthcoming alcohol strategy.
More police officers on patrol in accident and emergency departments are expected to be among the "innovative" solutions put forward by the prime minister.
"Whether it's the police officers in A&E that have been deployed in some hospitals, the booze buses in Soho and Norwich, or the drunk tanks used abroad, we need innovative solutions to confront the rising tide of unacceptable behaviour," he is expected to say.
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"This isn't just about more rules and regulation. It's about responsibility and a sense of respect for others," he will say, calling on the drinks industry, supermarkets, pubs and clubs to work with government to ensure that "responsible drinking becomes a reality and not just a slogan".
Labour has already indicated it also backs minimum pricing.
Last December, shadow public health minister Diane Abbott said "all the medical evidence points to the need for a minimum price per unit of alcohol. Alcohol abuse is not just a health issue, it is a public order issue".
According to Downing Street, there were 200,000 hospital admissions in 2010-11 with alcohol as the primary factor, which was 40% than in 2002-03.
The £2.7bn which alcohol abuse is estimated to cost the NHS each year equates to £90 for every taxpayer.
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